Borderline Personality Disorder: A Dysregulation of the Endogenous Opioid System?
Psychological Review © 2010 American Psychological Association 2010, Vol. 117, No. 2, 623– 636 0033-295X/10/$12.00 DOI: 10.1037/a0018095 Borwin Bandelow University of Gottingen Christian Schmahl Central Institute of Mental Health, Mannheim, Germany Peter Falkai and Dirk Wedekind University of Gottingen The neurobiology of borderline personality disorder (BPD) remains unclear. Dysfunctions of several neurobiological systems, including serotoninergic, dopaminergic, and other neurotransmitter systems, have been discussed. Here we present a theory that alterations in the sensitivity of opioid receptors or the…