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Tag: endogenous opioid system

Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

Published: 15 June 2017 Nadia Cattane, Roberta Rossi, Mariangela Lanfredi & Annamaria Cattaneo Abstract Background According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for…

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Borderline Personality Disorder: A Dysregulation of the Endogenous Opioid System?

Borderline Personality Disorder: A Dysregulation of the Endogenous Opioid System?

Psychological Review                                                                                                                                                                                          © 2010 American Psychological Association 2010, Vol. 117, No. 2,  623– 636                                                                                                                                                                      0033-295X/10/$12.00    DOI: 10.1037/a0018095   Borwin Bandelow University of Gottingen Christian Schmahl Central Institute of Mental Health, Mannheim, Germany Peter Falkai and Dirk Wedekind University of Gottingen   The neurobiology of borderline personality disorder (BPD) remains unclear. Dysfunctions of several neurobiological systems, including serotoninergic, dopaminergic, and other neurotransmitter systems, have been discussed. Here we present a theory that alterations in the sensitivity of opioid receptors or the…

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